Lasix belongs to a class of diuretics, it is prescribed in patients with swelling caused by congestive heart failure.
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Product Description
Diuretic Lasix acts by means of absorption of excessive amounts of salt in the body. At the core of the active substance Lasix furosemide, which is part of the oral tablet 20 mg, 40 mg and 80mg.
Lasix is used strictly by prescription. The active ingredient prevents the absorption of Lasix much salt body. Excess salt output with urination.
Do not take Lasix if you have kidney problems. Before taking Lasix should consult with your doctor and inform him about health problems such as kidney disease, gout, diabetes, or allergy to components of Lasix.
Pregnant women or women planning pregnancy should be required to discuss with the doctor the risks associated with taking Lasix, as it may harm the future of the fetus. Also pay attention to women breast-feeding, as Lasix may appear in breast milk.
On the chemical structure Lasix is a sulfonamide. This fast-acting diuretic, most of the effect of which is connected with the blockade of reabsorption of sodium and chloride ions in the ascending loop of Henle knee. The drug also influences the convoluted tubules, and this effect is not associated with inhibition of carbonic anhydrase or antialdosteronovoy activity. Lasix has a strong diuretic, natriyureticheskoe, hlorureticheskoe action. Also increases the excretion of potassium, calcium and magnesium.
When the pill inside the bioavailability of Lasix is 64%. The maximum concentration of drug in plasma increases with increasing dose, but the time to reach maximum does not depend on the dose and varies widely depending on the patient's condition. The half-life is approximately 2 hours after i / v injection Lasix excreted in the urine significantly longer than after oral administration. In blood plasma drug is mainly due to the protein, mainly to albumin: a range of concentrations from 1 to 400 ng / ml communication with the protein in healthy individuals is 91-99%. Free fraction of 2.5-4.1% of therapeutic concentrations. In the process of drug biotransformation in the body is converted primarily into glucuronide.
Reduces the preload on the heart, reduces the filling pressure of the left ventricle and pulmonary artery pressure by the expansion of large veins. It has a lowering effect. When administered in doses of 40 mg beginning of diuretic effect is observed for 60 min and duration in the range of 3-6 hours With a / in the beginning of the introduction of diuretic effect occurs within 15 minutes, the duration is within 3 hours
Common use
Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl- in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.
Dosage and direction
Take exactly as it was prescribed by your doctor.
Precautions
Before using Furosemide, consult your doctor if you suffer from kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated as Furosemide makes you urinate more often. Do not stop taking the drug even if you feel fine as high blood pressure often has no symptoms. Avoid taking the drug if you are pregnant or breastfeeding.
Contraindications
Hypersensitivity, acute kidney failure with anuria, severe liver failure, liver coma and precoma, stenois of urethra, acute glomerulonephritis, urinary tract obstruction, precoma, hyperglycemic coma, gout, arterial hypotension, heart attack, pancreatitis and others.
Possible side effect
Contact your physician for medical attention if you have signs of allergy or any following conditions: dry mouth, thirst, nausea, vomiting; weakness, drowsiness, restless, or light-headed, fast or uneven heartbeat, muscle pain, less than usual urination or absence of urination, easy bruising or bleeding, red blistering skin rash, hair loss.
Drug interaction
Hearing damage may occur if Furosemide is administered with aminoglycoside antibiotics (gentamicin and others) or Edecrin - another diuretic. Concomitant use of Furosemide and aspirin may cause high blood levels of aspirin and aspirin toxicity. Furosemide is able to reduce excretion of lithium by the kidneys. Sucralfate (Carafate) reduces the action of Furosemide. Intake of Ingestion of Furosemide and Sucralfate should be separated by two hours.
Missed dose
The medication is sometimes administered for single use so you will not need a dosing schedule. If you take Furosemide regularly and forgot to take a dose take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate the missed dose by taking an extra one.
Overdose
In case of loss of appetite, ringing in ears, severe weakness, dizziness, confusion, lightheadedness, or fainting, seek for immediate doctor's attention.
Storage
Keep away from children at room temperature in a dry and dark place.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
